Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

The sexual stages of P. falciparum adopt a unique crescent shape that is essential for transmission via mosquitoes. We provide 3D views of the elongating parasite at unprecedented resolution. Inducible genetic disruption reveals proteins that are essential for gametocyte elongation and survival. This work points to potential targets for the development of transmission-blocking therapies.