Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model

This world-first study identified that a very high proportion (80%) of P. vivax infections arise from dormant hypnozoites and sustain transmission. This study provided key evidence presented at 2017 WHO Expert Review Group Meeting demonstrating that currently available malaria control interventions will be insufficient to achieve elimination of P. vivax, highlighting the need to develop novel diagnostics and surveillance strategies.