Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model

Using an innovative design, this study proved that 80% of all P. vivax bloodstage infections are caused by relapses from long-lasting liverstages and using mathematical models we predicted that elimination of P. vivax will be difficult without attacking the silent hypnozoite reservoir.