Mayeta Clark 2015

Making the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugs

September 1, 2014

Our invited review highlighted that current pharmacokinetic-pharmacodynamic models exclude important factors such as host immunity and complexities of drug action. We highlighted a lack of statistical rigour in parameter estimation.

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Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria

July 1, 2014

This study demonstrated than human antibodies to merozoites promote opsonic phagocytosis by monocytes, which is was associated with protective immunity to malaria in Africa children. The acquisition and boosting of these antibodies was defined.

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Decreasing malaria prevalence and its potential consequences for immunity in pregnant women

May 5, 2014

In Malawi and Papua New Guinea, maternal antibodies fell as malaria transmission declined, but rates of fall differed between different types of malaria antibody response.

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Malaria burden and control in Bangladesh and prospects for elimination: an epidemiological and economic assessment

February 1, 2014

This original research quantifies the malaria burden and programmatic costs of malaria elimination in Bangladesh.

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Dihydroartemisinin-piperaquine treatment of multidrug resistant falciparum and vivax malaria in pregnancy

January 17, 2014

Background Artemisinin combination therapy (ACT) is recommended for the treatment of multidrug resistant malaria in the second and third trimesters…

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Major burden of severe anemia from non-falciparum malaria species in southern Papua: A hospital-based surveillance study

December 17, 2013

This paper highlights the central role of anaemia in the aetiology of severe vivax malaria.

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Low antibody levels to pregnancy-specific malaria antigens and heightened cytokine responses associated with severe malaria in pregnancy

November 25, 2013

Sudanese pregnant women with severe malaria had low levels of pregnancy-specific antibody suggesting low immunity, and had high blood cytokine levels. Lack of immunity may predispose to severe pregnancy malaria.

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Further shrinking the malaria map: How can geospatial science help achieve malaria elimination?

August 1, 2013

This paper outlines spatial decision support tools that have been adopted by control programs.

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Identification and prioritization of merozoite antigens as targets of protective human immunity to falciparum malaria for vaccine and biomarker development

June 17, 2013

The first comprehensive evaluation of merozoite antigens as targets of human immunity, including 96 antigens, which examined responses in detail in a longitudinal cohort of over 200 children. The study identified several antigens as strong targets of protective immunity that underpins a rational approach to vaccine development and biomarker development.

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Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

March 26, 2013

Antimalarial resistance is poorly understood, yet potentially devastating. We introduced a cutting edge experimental procedure and mathematical framework to probe the development of drug resistance.

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